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KMID : 0376219820190020121
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Chonnam Medical Journal
1982 Volume.19 No. 2 p.121 ~ p.130
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Activities of combined antibiotics against tobramycin-resistant Pseudomonas aeruginosa
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Abstract
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Various antibiotics have been used alone or in combination as the inhibitory agents of Pseudomonas aeruginosa (Ps.). Combinations between penicillins and aminoglycosides have, however, been most frequently used so far as the synergistic action is concerned.
Twenty strains of Ps. which had shown a considerable resistance(MIC ? 10 pg/ml) to tobramycin (TM) were chosen among recent isolates and submitted to the present experiment to see what drug combinations would bring about the most synergistic effect. Test antibiotics were gentamicin (GM), TM, carbenicillin (CB), and sulbenicillin (SB). The MICs of combined drugs were measured against each test organism by checkerboard dilution method. The synergism was determined by calculating the fractional inhibition concentration index (FICI), observing, the MIC distribution curve on the isobologram.
Results obtained were as follows:
All of the strains submitted were inhibited synergistically at least one of the four combinations, GM?CB, GM?SB, TM?CB, and TM?SB. Six strains (30%) were inhibited synergistically by all of the four combinations.
Of the four kinds of combination, TM?CB was most effective, i.e., all strains except one were inhibited synergistically by this combination. Considering the test organisms were originally resistant to TM, this high rate of synergism may be worthy of notice.
It is suggested that the pattern of combined drug action could not be predicted at all by the behavior of bacteria to single drug.
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